![]() ![]() It is excreted in the urine and in the faeces. It is widely distributed through the body tissues and fluids. Torin is incompletely absorbed from the gastro-intestinal tract, about 60 to 80% of a dose of tetracycline usually being available. Torin is also active against anaerobic species of bacteria and since concentrations of the drug are quite high in the gastrointestinal contents, the enteric flora are usually altered by the drug. Torin is also active against and is the drug of choice for Brucella species, Calymmatobacterium granulomatis, Vibrio cholerae and V. coli and consequently, Torin is still used in uncomplicated initial UTIs. ![]() Urinary concentrations are adequate for some community - acquired E. Pseudomonas and many Enterobacteriaceae are resistant. Thus, tetracycline is not the drug of choice in infections due to gram positive aerobes. Many Gram positive aerobic Cocci are susceptible, but many strains of staphylococci, streptococci and even some pneumococci are resistant to Torin. Once inside the bacterial cell, Torin binds specifically to the 30s ribosomes and inhibit bacterial protein synthesis. Torin has its main mechanism of action on protein synthesis, and an energy-dependent active transport system pumps the drug through the inner cytoplasmic membrane of bacteria. ![]()
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